About the Authors

Cydney B Nielsen

Contributed equally to this work with: Cydney B Nielsen, Brad Friedman

Affiliations Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, The Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, United States of America

Brad Friedman

Contributed equally to this work with: Cydney B Nielsen, Brad Friedman

Affiliations Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Department of Mathematics, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

Bruce Birren

Affiliation The Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, United States of America

Christopher B Burge

To whom correspondence should be addressed. E-mail: cburge@mit.edu (CB), Email: jgalag@mit.edu (JG)

Affiliation Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

James E Galagan

To whom correspondence should be addressed. E-mail: cburge@mit.edu (CB), Email: jgalag@mit.edu (JG)

Affiliation The Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, United States of America

Competing Interests

The authors have declared that no conflicts of interest exist.

Author Contributions

CBN, BB, CBB, and JEG conceived and designed the experiments. CBN, BF, and JEG analyzed the data. CBN, BF, and JEG contributed materials/analysis tools. CBN, BF, CBB, and JEG wrote the paper.