About the Authors

James A Fraser

Affiliations Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America, Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina, United States of America

Stephanie Diezmann

Affiliations Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America, Duke Institute for Genomics Sciences and Policy, Duke University Medical Center, Durham, North Carolina, United States of America

Ryan L Subaran

Affiliation Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America

Andria Allen

Affiliations Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America, Duke Institute for Genomics Sciences and Policy, Duke University Medical Center, Durham, North Carolina, United States of America

Klaus B Lengeler

address: Institut für Mikrobiologie, Heinrich-Heine-Universität, Düsseldorf, Germany

Affiliations Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America, Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina, United States of America

Fred S Dietrich

Affiliations Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America, Duke Institute for Genomics Sciences and Policy, Duke University Medical Center, Durham, North Carolina, United States of America

Joseph Heitman

To whom correspondence should be addressed. E-mail: heitm001@duke.edu

Affiliations Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America, Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina, United States of America, Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America, Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina, United States of America

Competing Interests

The authors have declared that no conflicts of interest exist.

Author Contributions

JAF and JH conceived and designed the experiments. JAF, RLS, AA, and KL performed the experiments. JAF, SD, FSD, and JH analyzed the data. JAF and FSD contributed reagents/materials/analysis tools. JAF and JH wrote the paper.