About the Authors

Bino John

Affiliation Computational Biology Center, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

Anton J Enright

Affiliations Computational Biology Center, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America, Wellcome Trust Sanger Institute, Cambridge, United Kingdom

Alexei Aravin

Affiliation Laboratory of RNA Molecular Biology, The Rockefeller University, New York, New York, United States of America

Thomas Tuschl

Affiliation Laboratory of RNA Molecular Biology, The Rockefeller University, New York, New York, United States of America

Chris Sander

Affiliation Computational Biology Center, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

Debora S Marks

To whom correspondence should be addressed. E-mail: mirnatargets@cbio.mskcc.org

Affiliation Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America

Competing Interests

The authors have declared that no conflicts of interest exist.

Author Contributions

CS and DMS conceived and directed the project. BJ, AJE, CS, and DSM worked on the algorithm. BJ, AJE, and DSM prepared the input data. BJ and AJE wrote the computer programs. BJ, AA, TT, CS, and DSM analyzed the ouput data. TT contributed microRNA expression data. BJ, CS, and DSM wrote the paper with assistance from AJE.