About the Authors

Patrick Eichenberger

Affiliation Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, United States of America

Masaya Fujita

Affiliation Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, United States of America

Shane T Jensen

Affiliation Department of Statistics, Harvard University, Cambridge, Massachusetts, United States of America

Erin M Conlon

Address Current address: Department of Mathematics and Statistics, University of Massachusetts, Amherst, Massachusetts, United States of America

Affiliation Department of Statistics, Harvard University, Cambridge, Massachusetts, United States of America

David Z Rudner

Address Current address: Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

Affiliation Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, United States of America

Stephanie T Wang

Affiliation Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, United States of America

Caitlin Ferguson

Affiliation Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, United States of America

Koki Haga

Affiliation International Environmental and Agricultural Science, Tokyo University of Agriculture and Technology, Fuchu, Tokyo, Japan

Tsutomu Sato

Affiliation International Environmental and Agricultural Science, Tokyo University of Agriculture and Technology, Fuchu, Tokyo, Japan

Jun S Liu

Affiliation Department of Statistics, Harvard University, Cambridge, Massachusetts, United States of America

Richard Losick

To whom correspondence should be addressed. E-mail: losick@mcb.harvard.edu

Affiliation Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, United States of America

Competing Interests

The authors have declared that no conflicts of interest exist.

Author Contributions

PE, MF, STJ, EMC, DZR, TS, JSL, and RL conceived and designed the experiments. PE, MF, DZR, STW, CF, and KH performed the experiments. PE, MF, STJ, EMC, DZR, and JSL analyzed the data. PE, MF, STJ, EMC, DZR, and JSL contributed reagents/materials/analysis tools. PE, MF, STJ, EMC, JSL, and RL wrote the paper.