About the Authors

Seth Blackshaw

Affiliation Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts, United States of America

Sanjiv Harpavat

Affiliation Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts, United States of America

Jeff Trimarchi

Affiliation Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts, United States of America

Li Cai

Affiliation Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America

Haiyan Huang

Affiliation Department of Statistics, University of California, Berkeley, California, United States of America

Winston P Kuo

Affiliations Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts, United States of America, Children's Hospital Informatics Program, Boston, Massachusetts, United States of America

Griffin Weber

Affiliation Decision Systems Group, Brigham and Women's Hospital, Boston, Massachusetts, United States of America

Kyungjoon Lee

Affiliation Children's Hospital Informatics Program, Boston, Massachusetts, United States of America

Rebecca E Fraioli

Affiliation Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts, United States of America

Seo-Hee Cho

Affiliation Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts, United States of America

Rachel Yung

Affiliation Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts, United States of America

Elizabeth Asch

Affiliation Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts, United States of America

Lucila Ohno-Machado

Affiliation Decision Systems Group, Brigham and Women's Hospital, Boston, Massachusetts, United States of America

Wing H Wong

Affiliation Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America

Constance L Cepko

To whom correspondence should be addressed. E-mail: cepko@genetics.med.harvard.edu

Affiliation Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts, United States of America

Competing Interests

The authors have declared that no conflicts of interest exist.

Author Contributions

SB and CLC conceived and designed the experiments. SB, SH, JT, REF, RY, and EA performed the experiments. SB, LC, HH, and WHW analyzed the data. S-HC edited photomicrographs. SB, LC, HH, WPK, KL, LM-O, GW, and WHW contributed reagents/materials/analysis tools. SB and CLC wrote the paper.