About the Authors

David G Ransom

Address address: Department of Cell and Developmental Biology, Oregon Health and Science University, Portland, Oregon, United States of America

Affiliation Division of Hematology/Oncology, Children's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Nathan Bahary

Affiliation Division of Hematology/Oncology, Children's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Knut Niss

Affiliation Division of Hematology/Oncology, Children's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

David Traver

Affiliation Division of Hematology/Oncology, Children's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Caroline Burns

Affiliation Division of Hematology/Oncology, Children's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Nikolaus S Trede

Affiliation Division of Hematology/Oncology, Children's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Noelle Paffett-Lugassy

Affiliation Division of Hematology/Oncology, Children's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Walter J Saganic

Affiliation Division of Hematology/Oncology, Children's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

C. Anthoney Lim

Affiliation Division of Hematology/Oncology, Children's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Candace Hersey

Affiliation Division of Hematology/Oncology, Children's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Yi Zhou

Affiliation Division of Hematology/Oncology, Children's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Bruce A Barut

Affiliations Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America, Division of Hematology/Oncology, Children's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Shuo Lin

Affiliation Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, California, United States of America

Paul D Kingsley

Affiliation Department of Pediatrics and Center for Human Genetics and Molecular Pediatric Disease, University of Rochester Medical Center, Rochester, New York, United States of America

James Palis

Affiliation Department of Pediatrics and Center for Human Genetics and Molecular Pediatric Disease, University of Rochester Medical Center, Rochester, New York, United States of America

Stuart H Orkin

Affiliations Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America, Division of Hematology/Oncology, Children's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Leonard I Zon

Affiliations Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America, Division of Hematology/Oncology, Children's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Competing Interests

The authors have declared that no conflicts of interest exist.

Author Contributions

DGR, NB, KN, DT, CB, NST, YZ, JP, SHO, and LIZ conceived and designed the experiments. DGR, NB, KN, DT, CB, NST, NPL, WJS, CAL, CH, BAB, and PDK performed the experiments. DGR, NB, KN, DT, CB, NST, NPL, YZ, JP, SHO, and LIZ analyzed the data. DGR, NB, KN, DT, NST, YZ, BAB, SL, and JP contributed reagents/materials/analysis tools. DGR, NB, KN, DT, and LIZ wrote the paper.