JAMM: A Metalloprotease-Like Zinc Site in the Proteasome and Signalosome

Xavier I Ambroggio; Douglas C Rees; Raymond J Deshaies

doi:10.1371/journal.pbio.0020002

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Open Access

Peer-reviewed

Research Article

JAMM: A Metalloprotease-Like Zinc Site in the Proteasome and Signalosome

Xavier I Ambroggio,

Affiliation Division of Biology, California Institute of Technology, Pasadena, California, United States of America
⨯
Douglas C Rees,

Affiliations Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California, United States of America, Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America
⨯
Raymond J Deshaies

*To whom correspondence should be addressed. E-mail: deshaies@caltech.edu

Affiliations Division of Biology, California Institute of Technology, Pasadena, California, United States of America, Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America
⨯

JAMM: A Metalloprotease-Like Zinc Site in the Proteasome and Signalosome

Xavier I Ambroggio,
Douglas C Rees,
Raymond J Deshaies

Published: November 24, 2003
https://doi.org/10.1371/journal.pbio.0020002

About the Authors

Xavier I Ambroggio

Affiliation Division of Biology, California Institute of Technology, Pasadena, California, United States of America

Douglas C Rees

Affiliations Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California, United States of America, Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America

Raymond J Deshaies

*To whom correspondence should be addressed. E-mail: deshaies@caltech.edu

Affiliations Division of Biology, California Institute of Technology, Pasadena, California, United States of America, Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America

Competing Interests

The authors have declared that no conflicts of interest exist.

Author Contributions

XIA, DCR, and RJD conceived and designed the experiments. XIA performed the experiments. XIA, DCR, and RJD analyzed the data. XIA, DCR, and RJD contributed reagents/materials/analysis tools. XIA wrote the paper.

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Zinc
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Proteasomes
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Proteomic databases
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Crystal structure
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Crystals
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Metalloproteases
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Cancer treatment
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Serine
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