About the Authors

Maisem Laabei

Affiliation Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom

Anne-Catrin Uhlemann

Affiliation Department of Medicine, Columbia University, New York, New York, United States of America

Franklin D. Lowy

Affiliation Department of Medicine, Columbia University, New York, New York, United States of America

Eloise D. Austin

Affiliation Department of Medicine, Columbia University, New York, New York, United States of America

Maho Yokoyama

Affiliation Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom

Khadija Ouadi

Affiliation Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom

Edward Feil

Affiliation Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom

Harry A. Thorpe

Affiliation Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom

Barnabas Williams

Affiliation Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom

Mark Perkins

Affiliation Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom

Sharon J. Peacock

Affiliation Department of Medicine, University of Cambridge, Cambridge, United Kingdom

Stephen R. Clarke

Affiliation School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff, United Kingdom

Janina Dordel

Affiliation Pathogen Genomics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom

Matthew Holden

Affiliations Pathogen Genomics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom, School of Medicine, Medical & Biological Sciences, North Haugh, St Andrews, Fife, United Kingdom

Antonina A. Votintseva

Affiliation Nuffield Dept. of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom

Rory Bowden

Affiliation Wellcome Trust Centre for Human Genetics, Oxford, United Kingdom

Derrick W. Crook

Affiliation Nuffield Dept. of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom

Bernadette C. Young

Affiliation Nuffield Dept. of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom

Daniel J. Wilson

Contributed equally to this work with: Daniel J. Wilson, Mario Recker, Ruth C. Massey

Affiliations Nuffield Dept. of Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom, Wellcome Trust Centre for Human Genetics, Oxford, United Kingdom

Mario Recker

Contributed equally to this work with: Daniel J. Wilson, Mario Recker, Ruth C. Massey

Affiliation Centre for Mathematics and the Environment, University of Exeter, Penryn Campus, Penryn, United Kingdom

Ruth C. Massey

Contributed equally to this work with: Daniel J. Wilson, Mario Recker, Ruth C. Massey

r.c.massey@bath.ac.uk

Affiliation Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ML ACU FDL SJP SRC DJW MR RCM. Performed the experiments: ML ACU EDA MY KO HAT BW MP SRC JD MH AAV RB BCY DJW MR RCM. Analyzed the data: ML DJW MR RCM. Contributed reagents/materials/analysis tools: ACU FDL EF SJP DWC BCY DJW RCM. Wrote the paper: ML DJW MR RCM.