About the Authors

Chen Wang

Contributed equally to this work with: Chen Wang, Jiayan Sang

Affiliations State Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiangan, Xiamen, China, Department of Molecular and Computational Biology, University of Southern California, Los Angeles, California, United States of America

Jiayan Sang

Contributed equally to this work with: Chen Wang, Jiayan Sang

Affiliation State Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiangan, Xiamen, China

Jiawei Wang

Affiliation Department of Biology and Technology, Tsinghua University, Beijing, China

Mingyan Su

Affiliation State Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiangan, Xiamen, China

Jennifer S. Downey

Affiliation Division of Biomedical Science, Herman Ostrow School of Dentistry of University of Southern California, Los Angeles, California, United States of America

Qinggan Wu

Affiliation State Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiangan, Xiamen, China

Shida Wang

Affiliation Dental Research Institute, Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada

Yongfei Cai

Affiliation State Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiangan, Xiamen, China

Xiaozheng Xu

Affiliation State Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiangan, Xiamen, China

Jun Wu

Affiliation State Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiangan, Xiamen, China

Dilani B. Senadheera

Affiliation Dental Research Institute, Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada

Dennis G. Cvitkovitch

Affiliation Dental Research Institute, Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada

Lin Chen

Affiliation Department of Molecular and Computational Biology, University of Southern California, Los Angeles, California, United States of America

Steven D. Goodman

Affiliation Division of Biomedical Science, Herman Ostrow School of Dentistry of University of Southern California, Los Angeles, California, United States of America

Aidong Han

ahan@xmu.edu.cn

Affiliation State Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiangan, Xiamen, China

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Initiated this project: AH LC SDG DBS DGC. Purified and crystallized proteins: CW. Performed mutagenesis and biochemical assays: JS MS QW XX SW JW. Solved and refined structure: JWW YC. Made initial expression constructs: JSD. Analyzed the data: AH. Contributed reagents/materials/analysis tools: AH LC SDG. Wrote the paper: AH.