About the Authors
- Christoph Kleinschnitz
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* E-mail: h.schmidt@farmaco.unimaas.nl (HHHWS); christoph.kleinschnitz@mail.uni-wuerzburg.de (CK)
Affiliation Neurologische Klinik und Poliklinik, Universität Würzburg, Würzburg, Germany
- Henrike Grund
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Affiliation Rudolf-Buchheim-Institut für Pharmakologie & Medizinische Klinik, Justus-Liebig-Universität, Gießen, Germany
- Kirstin Wingler
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Affiliations Rudolf-Buchheim-Institut für Pharmakologie & Medizinische Klinik, Justus-Liebig-Universität, Gießen, Germany, Department of Pharmacology and Centre for Vascular Health, Monash University, Melbourne, Australia, Department of Pharmacology and Toxicology and Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, The Netherlands, National Stroke Research Institute, Florey Neuroscience Institutes, Melbourne, Australia
- Melanie E. Armitage
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Affiliations Department of Pharmacology and Centre for Vascular Health, Monash University, Melbourne, Australia, National Stroke Research Institute, Florey Neuroscience Institutes, Melbourne, Australia
- Emma Jones
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Affiliation Department of Pharmacology and Centre for Vascular Health, Monash University, Melbourne, Australia
- Manish Mittal
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Affiliation Rudolf-Buchheim-Institut für Pharmakologie & Medizinische Klinik, Justus-Liebig-Universität, Gießen, Germany
- David Barit
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Affiliation Baker IDI Heart and Diabetes Institute, Juvenile Diabetes Research Foundation (JDRF) International Center for Diabetic Complications Research, Melbourne, Australia
- Tobias Schwarz
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Affiliation Neurologische Klinik und Poliklinik, Universität Würzburg, Würzburg, Germany
- Christian Geis
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Affiliation Neurologische Klinik und Poliklinik, Universität Würzburg, Würzburg, Germany
- Peter Kraft
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Affiliation Neurologische Klinik und Poliklinik, Universität Würzburg, Würzburg, Germany
- Konstanze Barthel
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Affiliation Abteilung Neurologie, Georg-August Universität Göttingen, Göttingen, Germany
- Michael K. Schuhmann
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Affiliations Neurologische Klinik und Poliklinik, Universität Würzburg, Würzburg, Germany, Universitätsklinik Münster, Klinik und Poliklinik für Neurologie—Entzündliche Erkrankungen des Nervensystems und Neuroonkologie, Münster, Germany
- Alexander M. Herrmann
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Affiliations Neurologische Klinik und Poliklinik, Universität Würzburg, Würzburg, Germany, Universitätsklinik Münster, Klinik und Poliklinik für Neurologie—Entzündliche Erkrankungen des Nervensystems und Neuroonkologie, Münster, Germany
- Sven G. Meuth
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Affiliations Neurologische Klinik und Poliklinik, Universität Würzburg, Würzburg, Germany, Universitätsklinik Münster, Klinik und Poliklinik für Neurologie—Entzündliche Erkrankungen des Nervensystems und Neuroonkologie, Münster, Germany
- Guido Stoll
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Affiliation Neurologische Klinik und Poliklinik, Universität Würzburg, Würzburg, Germany
- Sabine Meurer
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Affiliation Department of Pharmacology and Centre for Vascular Health, Monash University, Melbourne, Australia
- Anja Schrewe
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Affiliation Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, München, Germany
- Lore Becker
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Affiliations Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, München, Germany, Friedrich-Baur-Institut an der Neurologischen Klinik, Klinikum der Ludwig-Maximilians-Universität München, München, Germany
- Valérie Gailus-Durner
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Affiliation Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, München, Germany
- Helmut Fuchs
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Affiliation Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, München, Germany
- Thomas Klopstock
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Affiliation Friedrich-Baur-Institut an der Neurologischen Klinik, Klinikum der Ludwig-Maximilians-Universität München, München, Germany
- Martin Hrabé de Angelis
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Affiliations Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, München, Germany, Lehrstuhl für Experimentelle Genetik, Technische Universität München, Freising-Weihenstephan, Germany
- Karin Jandeleit-Dahm
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Affiliation Baker IDI Heart and Diabetes Institute, Juvenile Diabetes Research Foundation (JDRF) International Center for Diabetic Complications Research, Melbourne, Australia
- Ajay M. Shah
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Affiliation King's College London School of Medicine, The James Black Centre, Cardiovascular Division, London, United Kingdom
- Norbert Weissmann
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Affiliation Rudolf-Buchheim-Institut für Pharmakologie & Medizinische Klinik, Justus-Liebig-Universität, Gießen, Germany
- Harald H. H. W. Schmidt
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* E-mail: h.schmidt@farmaco.unimaas.nl (HHHWS); christoph.kleinschnitz@mail.uni-wuerzburg.de (CK)
Affiliations Rudolf-Buchheim-Institut für Pharmakologie & Medizinische Klinik, Justus-Liebig-Universität, Gießen, Germany, Department of Pharmacology and Centre for Vascular Health, Monash University, Melbourne, Australia, Department of Pharmacology and Toxicology and Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, The Netherlands, National Stroke Research Institute, Florey Neuroscience Institutes, Melbourne, Australia
Competing Interests
HHHWS and KW declare a potential competing interest as shareholder and previous employee, respectively, of Vasopharm GmbH, which develops NADPH oxidase inhibitors such as VAS2870. All authors declare that they adhere to all PLoS Biology policies on sharing data and materials as detailed in the PLoS Biology guide for authors.
Author Contributions
The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: CK AS MHdA KJD NW HHS. Performed the experiments: CK HG MEA EJ MM DB TS CG PK KB MKS AMH SGM GS SM AS LB VGD HF TK. Analyzed the data: CK MEA EJ MM DB LB VGD HF TK MHdA KJD NW HHHWS. Contributed reagents/materials/analysis tools: CK HG KW AMS HHHWS. Wrote the paper: CK KW HHHWS.