About the Authors

Mathias Beller

To whom correspondence should be addressed. E-mail: mbeller@gwdg.de (M. Beller); csztalry@grecc.umaryland.edu (C. Sztalryd); oliver@helix.nih.gov (B. Oliver)

Affiliations Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America , Max-Planck-Institut für biophysikalische Chemie, Abteilung für Molekulare Entwicklungsbiologie, Göttingen, Germany

Carole Sztalryd

To whom correspondence should be addressed. E-mail: mbeller@gwdg.de (M. Beller); csztalry@grecc.umaryland.edu (C. Sztalryd); oliver@helix.nih.gov (B. Oliver)

Affiliations Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America , GRECC/Geriatrics, Veterans Affairs Medical Center, Department of Medicine, School of Medicine, University of Maryland, Baltimore, Maryland, United States of America

Noel Southall

Affiliation NIH Chemical Genomics Center, National Institutes of Health, Bethesda, Maryland, United States of America

Ming Bell

Affiliation GRECC/Geriatrics, Veterans Affairs Medical Center, Department of Medicine, School of Medicine, University of Maryland, Baltimore, Maryland, United States of America

Herbert Jäckle

Affiliation Max-Planck-Institut für biophysikalische Chemie, Abteilung für Molekulare Entwicklungsbiologie, Göttingen, Germany

Douglas S Auld

Affiliation NIH Chemical Genomics Center, National Institutes of Health, Bethesda, Maryland, United States of America

Brian Oliver

To whom correspondence should be addressed. E-mail: mbeller@gwdg.de (M. Beller); csztalry@grecc.umaryland.edu (C. Sztalryd); oliver@helix.nih.gov (B. Oliver)

Affiliation Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

M. Beller, C. Sztalryd, and B. Oliver designed the study. Drosophila RNAi screen was performed by M. Beller and B. Oliver, mammalian siRNA screen by C. Sztalryd, and M. Bell, small-molecule compound experiments by N. Southall and D. S. Auld, and data analysis was by M. Beller. M. Beller, C. Sztalryd, H. Jäckle, and B. Oliver prepared the manuscript.