About the Authors

Xiao-yong Li

Contributed equally to this work with: Xiao-yong Li, Stewart MacArthur

Affiliation Genomics Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America

Stewart MacArthur

Contributed equally to this work with: Xiao-yong Li, Stewart MacArthur

Affiliation Genomics Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America

Richard Bourgon

Current address: EMBL-EBI, Hinxton, Cambridgeshire, United Kingdom

Affiliation Statistics Department, University of California Berkeley, Berkeley, California, United States of America

David Nix

Current address: Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, United States of America

Affiliation Genomics Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America

Daniel A Pollard

Affiliation Biophysics Graduate Group, University of California Berkeley, Berkeley, California, United States of America

Venky N Iyer

Affiliation Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California, United States of America

Aaron Hechmer

Affiliation Genomics Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America

Lisa Simirenko

Affiliation Genomics Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America

Mark Stapleton

Affiliation Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America

Cris L. Luengo Hendriks

Affiliation Biophysics Graduate Group, University of California Berkeley, Berkeley, California, United States of America

Hou Cheng Chu

Affiliation Genomics Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America

Nobuo Ogawa

Affiliation Genomics Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America

William Inwood

Affiliation Genomics Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America

Victor Sementchenko

Affiliation Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America

Amy Beaton

Affiliation Biophysics Graduate Group, University of California Berkeley, Berkeley, California, United States of America

Richard Weiszmann

Affiliation Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America

Susan E Celniker

Affiliation Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America

David W Knowles

Affiliation Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America

Tom Gingeras

Affiliation Affymetrix, Inc., Santa Clara, California, United States of America

Terence P Speed

Affiliation Statistics Department, University of California Berkeley, Berkeley, California, United States of America

Michael B Eisen

To whom correspondence should be addressed. E-mail: mbeisen@lbl.gov (MBE); mdbiggin@lbl.gov (MDB)

These authors are joint senior authors on this work.

Affiliations Genomics Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America , Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California, United States of America , Center for Integrative Genomics, University of California Berkeley, Berkeley, California, United States of America , California Institute for Quantitative Biosciences, Berkeley, California, United States of America

Mark D Biggin

To whom correspondence should be addressed. E-mail: mbeisen@lbl.gov (MBE); mdbiggin@lbl.gov (MDB)

These authors are joint senior authors on this work.

Affiliation Genomics Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

XL, SM, MBE, and MDB conceived and designed the experiments and analyses and wrote the paper. XL, HCC, WI performed the experiments. XL, SM, RB. DN, DAP, VNI, AH, CLLH, MBE, and MDB analyzed the data. DAP, VNI, AH, LS, MS, CLLH, HCC, NO, WI, VS, AB, RW, SEC, DWK, TG, TPS, MBE, and MDB contributed reagents/materials/analysis tools.