High Guanine and Cytosine Content Increases mRNA Levels in Mammalian Cells

Grzegorz Kudla; Leszek Lipinski; Fanny Caffin; Aleksandra Helwak; Maciej Zylicz

doi:10.1371/journal.pbio.0040180

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Open Access

Peer-reviewed

Research Article

High Guanine and Cytosine Content Increases mRNA Levels in Mammalian Cells

Grzegorz Kudla ,

Contributed equally to this work with: Grzegorz Kudla, Leszek Lipinski

*To whom correspondence should be addressed. E-mail: gkudla@cgr.harvard.edu

¤ Current address: Harvard University, Bauer Center for Genomics Research, Cambridge, United States of America

Affiliation International Institute of Molecular and Cell Biology, Warsaw, Poland
⨯
Leszek Lipinski ,

Contributed equally to this work with: Grzegorz Kudla, Leszek Lipinski

Affiliations International Institute of Molecular and Cell Biology, Warsaw, Poland , Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland
⨯
Fanny Caffin,

Affiliation International Institute of Molecular and Cell Biology, Warsaw, Poland
⨯
Aleksandra Helwak,

Affiliations International Institute of Molecular and Cell Biology, Warsaw, Poland , Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland
⨯
Maciej Zylicz

Affiliation International Institute of Molecular and Cell Biology, Warsaw, Poland
⨯

High Guanine and Cytosine Content Increases mRNA Levels in Mammalian Cells

Grzegorz Kudla,
Leszek Lipinski,
Fanny Caffin,
Aleksandra Helwak,
Maciej Zylicz

Published: May 23, 2006
https://doi.org/10.1371/journal.pbio.0040180

About the Authors

Grzegorz Kudla

Contributed equally to this work with: Grzegorz Kudla, Leszek Lipinski

*To whom correspondence should be addressed. E-mail: gkudla@cgr.harvard.edu

¤ Current address: Harvard University, Bauer Center for Genomics Research, Cambridge, United States of America

Affiliation International Institute of Molecular and Cell Biology, Warsaw, Poland

Leszek Lipinski

Contributed equally to this work with: Grzegorz Kudla, Leszek Lipinski

Affiliations International Institute of Molecular and Cell Biology, Warsaw, Poland , Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland

Fanny Caffin

Affiliation International Institute of Molecular and Cell Biology, Warsaw, Poland

Aleksandra Helwak

Affiliations International Institute of Molecular and Cell Biology, Warsaw, Poland , Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland

Maciej Zylicz

Affiliation International Institute of Molecular and Cell Biology, Warsaw, Poland

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

GK and LL conceived and designed the experiments. GK, LL, FC, and AH performed the experiments. GK, LL, and MZ analyzed the data. MZ contributed reagents/materials/analysis tools. GK wrote the paper.

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Messenger RNA
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Transfection
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Gene expression
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HeLa cells
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Nucleotides
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Reverse transcriptase-polymerase chain reaction
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Cloning
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293T cells
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