About the Authors

Sally Lowell

To whom correspondence should be addressed. E-mail: sally.lowell@ed.ac.uk (SL), Email: austin.smith@ed.ac.uk (AS)

Affiliation Centre Development in Stem Cell Biology, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom

Alexandra Benchoua

Affiliations Centre Development in Stem Cell Biology, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom , INSERM U 421/I-STEM, Faculté de Médecine, Evry-Cedex, France

Barry Heavey

Affiliation Centre Development in Stem Cell Biology, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom

Austin G Smith

To whom correspondence should be addressed. E-mail: sally.lowell@ed.ac.uk (SL), Email: austin.smith@ed.ac.uk (AS)

Affiliations Centre Development in Stem Cell Biology, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom , Institute for Stem Cell Biology, University of Cambridge, Cambridge, United Kingdom

Competing Interests

The University of Edinburgh has filed a patent application relating to this work on the use of Notch to control ES cell lineage commitment. This patent has been licensed to Stem Cell Sciences Ltd. AGS holds nonvoting equity (approximately 0.5%) in Stem Cell Sciences Ltd. BH has been employed by the company.

Author Contributions

SL, AB, BH, and AGS conceived and designed the experiments. SL, AB, and BH performed the experiments. SL, AB, BH, and AGS analyzed the data. SL and AGS wrote the paper.