Lipoprotein Genotype and Conserved Pathway for Exceptional Longevity in Humans

Gil Atzmon; Marielisa Rincon; Clyde B Schechter; Alan R Shuldiner; Richard B Lipton; Aviv Bergman; Nir Barzilai

doi:10.1371/journal.pbio.0040113

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Peer-reviewed

Research Article

Lipoprotein Genotype and Conserved Pathway for Exceptional Longevity in Humans

Gil Atzmon ,

Contributed equally to this work with: Gil Atzmon, Marielisa Rincon

Affiliations Institute for Aging Research, Albert Einstein College of Medicine, Bronx, New York, United States of America , Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, New York, United States of America
⨯
Marielisa Rincon ,

Contributed equally to this work with: Gil Atzmon, Marielisa Rincon

Affiliation Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York, United States of America
⨯
Clyde B Schechter,

Affiliations Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, New York, United States of America , Department of Family and Social Medicine, Albert Einstein College of Medicine, Bronx, New York, United States of America , Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, United States of America
⨯
Alan R Shuldiner,

Affiliation University of Maryland School of Medicine, and the Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, Maryland, United States of America
⨯
Richard B Lipton,

Affiliations Institute for Aging Research, Albert Einstein College of Medicine, Bronx, New York, United States of America , Department of Neurology, Albert Einstein College of Medicine, Bronx, New York, United States of America , Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, United States of America
⨯
Aviv Bergman,

Affiliation Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, United States of America
⨯
Nir Barzilai

*To whom correspondence should be addressed. E-mail: barzilai@aecom.yu.edu

Affiliations Institute for Aging Research, Albert Einstein College of Medicine, Bronx, New York, United States of America , Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, New York, United States of America
⨯

Lipoprotein Genotype and Conserved Pathway for Exceptional Longevity in Humans

Gil Atzmon,
Marielisa Rincon,
Clyde B Schechter,
Alan R Shuldiner,
Richard B Lipton,
Aviv Bergman,
Nir Barzilai

Published: April 4, 2006
https://doi.org/10.1371/journal.pbio.0040113

About the Authors

Gil Atzmon

Contributed equally to this work with: Gil Atzmon, Marielisa Rincon

Affiliations Institute for Aging Research, Albert Einstein College of Medicine, Bronx, New York, United States of America , Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, New York, United States of America

Marielisa Rincon

Contributed equally to this work with: Gil Atzmon, Marielisa Rincon

Affiliation Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York, United States of America

Clyde B Schechter

Affiliations Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, New York, United States of America , Department of Family and Social Medicine, Albert Einstein College of Medicine, Bronx, New York, United States of America , Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, United States of America

Alan R Shuldiner

Affiliation University of Maryland School of Medicine, and the Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, Maryland, United States of America

Richard B Lipton

Affiliations Institute for Aging Research, Albert Einstein College of Medicine, Bronx, New York, United States of America , Department of Neurology, Albert Einstein College of Medicine, Bronx, New York, United States of America , Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, United States of America

Aviv Bergman

Affiliation Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, United States of America

Nir Barzilai

*To whom correspondence should be addressed. E-mail: barzilai@aecom.yu.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

NB conceived and designed the experiments. GA, MR, and NB performed the experiments. GA, CBS, ARS, RBL, AB, and NB analyzed the data. GA, MR, CBS, ARS, RBL, AB, and NB contributed reagents/materials/analysis tools. GA, MR, CBS, ARS, RBL, AB, and NB wrote the paper.

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Lipoproteins
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Insulin
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Haplotypes
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Single nucleotide polymorphisms
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Apolipoproteins
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Homozygosity
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Variant genotypes
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Lipoprotein metabolism
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