About the Authors

Tammie Bishop

Affiliation The Henry Wellcome Building of Genomic Medicine, University of Oxford, Oxford, United Kingdom

Kah Weng Lau

Affiliation The Henry Wellcome Building of Genomic Medicine, University of Oxford, Oxford, United Kingdom

Andrew C. R Epstein

Affiliation The Henry Wellcome Building of Genomic Medicine, University of Oxford, Oxford, United Kingdom

Stuart K Kim

Affiliation Department of Developmental Biology and Genetics, Stanford University Medical Center, Stanford, California, United States of America

Min Jiang

Affiliation Department of Developmental Biology and Genetics, Stanford University Medical Center, Stanford, California, United States of America

Delia O'Rourke

Affiliation Department of Biochemistry, University of Oxford, Oxford, United Kingdom

Christopher W Pugh

Affiliation The Henry Wellcome Building of Genomic Medicine, University of Oxford, Oxford, United Kingdom

Jonathan M Gleadle

Affiliation The Henry Wellcome Building of Genomic Medicine, University of Oxford, Oxford, United Kingdom

Martin S Taylor

Affiliation The Henry Wellcome Building of Genomic Medicine, University of Oxford, Oxford, United Kingdom

Jonathan Hodgkin

Affiliation Department of Biochemistry, University of Oxford, Oxford, United Kingdom

Peter J Ratcliffe

To whom correspondence should be addressed. E-mail: pjr@well.ox.ac.uk

Affiliation The Henry Wellcome Building of Genomic Medicine, University of Oxford, Oxford, United Kingdom

Competing Interests

The authors have declared that no conflicts of interest exist.

Author Contributions

TB, KWL, ACRE, CWP, JH, and PJR conceived and designed the experiments. TB, KWL, ACRE, MJ, and DOR performed the experiments. TB, KWL, CWP, JMG, MST, JH, and PJR analyzed the data. MST designed and implemented the computational analyses. SKK, JH, and PJR contributed reagents/materials/analysis tools. TB and PJR wrote the paper.