Mimotopes for Alloreactive and Conventional T Cells in a Peptide–MHC Display Library

Frances Crawford; Eric Huseby; Janice White; Philippa Marrack; John W Kappler

doi:10.1371/journal.pbio.0020090

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Open Access

Peer-reviewed

Research Article

Mimotopes for Alloreactive and Conventional T Cells in a Peptide–MHC Display Library

Frances Crawford,

Affiliations Howard Hughes Medical Institute, Integrated Department of Immunology, National Jewish Medical and Research Center, Denver, Colorado, United States of America, Integrated Department of Immunology, University of Colorado Health Science Center, Denver, Colorado, United States of America
⨯
Eric Huseby,

Affiliations Howard Hughes Medical Institute, Integrated Department of Immunology, National Jewish Medical and Research Center, Denver, Colorado, United States of America, Integrated Department of Immunology, University of Colorado Health Science Center, Denver, Colorado, United States of America
⨯
Janice White,

Affiliation Howard Hughes Medical Institute, Integrated Department of Immunology, National Jewish Medical and Research Center, Denver, Colorado, United States of America
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Philippa Marrack,

Affiliations Howard Hughes Medical Institute, Integrated Department of Immunology, National Jewish Medical and Research Center, Denver, Colorado, United States of America, Integrated Department of Immunology, University of Colorado Health Science Center, Denver, Colorado, United States of America, Department of Biochemistry and Molecular Genetics, University of Colorado Health Science Center, Denver, Colorado, United States of America
⨯
John W Kappler

*To whom correspondence should be addressed. E-mail: kapplerj@njc.org

Affiliations Howard Hughes Medical Institute, Integrated Department of Immunology, National Jewish Medical and Research Center, Denver, Colorado, United States of America, Integrated Department of Immunology, University of Colorado Health Science Center, Denver, Colorado, United States of America, Department of Pharmacology and the Program in Biomolecular Structure, University of Colorado Health Science Center, Denver, Colorado, United States of America
⨯

Mimotopes for Alloreactive and Conventional T Cells in a Peptide–MHC Display Library

Frances Crawford,
Eric Huseby,
Janice White,
Philippa Marrack,
John W Kappler

Published: April 13, 2004
https://doi.org/10.1371/journal.pbio.0020090

About the Authors

Frances Crawford

Eric Huseby

Janice White

Affiliation Howard Hughes Medical Institute, Integrated Department of Immunology, National Jewish Medical and Research Center, Denver, Colorado, United States of America

Philippa Marrack

Affiliations Howard Hughes Medical Institute, Integrated Department of Immunology, National Jewish Medical and Research Center, Denver, Colorado, United States of America, Integrated Department of Immunology, University of Colorado Health Science Center, Denver, Colorado, United States of America, Department of Biochemistry and Molecular Genetics, University of Colorado Health Science Center, Denver, Colorado, United States of America

John W Kappler

*To whom correspondence should be addressed. E-mail: kapplerj@njc.org

Affiliations Howard Hughes Medical Institute, Integrated Department of Immunology, National Jewish Medical and Research Center, Denver, Colorado, United States of America, Integrated Department of Immunology, University of Colorado Health Science Center, Denver, Colorado, United States of America, Department of Pharmacology and the Program in Biomolecular Structure, University of Colorado Health Science Center, Denver, Colorado, United States of America

Competing Interests

The authors have declared that no conflicts of interest exist.

Author Contributions

FC and JWK conceived and designed the experiments. FC, EH, JW, and JWK performed the experiments. JWK and PM wrote the paper

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T cells
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Insects
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Peptide libraries
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Hybridomas
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Major histocompatibility complex
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Antigen-presenting cells
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Cell binding
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Library screening
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