Aimee Quitmeyer is an undergraduate student and Rebecca Roberts is Associate Professor with the Department of Biology, Ursinus College, Collegeville, Pennsylvania, United States of America. Rebecca Roberts is also Associate Professor and Coordinator of the Biochemistry and Molecular Biology Program at Ursinus College, Collegeville, Pennsylvania, United States of America.
A scientist and mother who studies bisphenol A, a chemical found in plastic baby bottles and cups, wrestles with the disconnect between scientific evidence that the chemical poses a special risk to children and current laws and regulations.
My 11-month-old daughter loves her baby bottles and sippy cups (first-person narrative is from the viewpoint of Rebecca Roberts). But as I sit and watch her drink from them, I cringe, because I happen to be a scientist who studies a chemical found in those bottles and cups. I also know that some scientific research suggests that exposure to that compound, called bisphenol A (BPA), is detrimental to good health—something I can't help but think about as I watch my daughter use her sippy cup as a teething ring.
As a scientist, I depend on evidence, logic, and imagination to explain observations made in the laboratory. I then interpret and communicate my findings to the scientific community and the public. As a mother, I strive to raise a healthy and happy child. I make daily decisions about what my baby does and does not do, in order to limit her exposure to danger. In both of my roles, I depend on information: nonbiased, factual, evidence-based information. The mother in me relies on my training as a scientist to objectively look at scientific data in order to determine personal choices for my daughter. But, like all people, I am not qualified, nor do I have the time, to understand all scientific issues. I must rely on others—on the brokers of information: other scientists, medical personnel, the government, regulatory agencies, corporations, nonprofit organizations, and the media, to name a few.
The purveyors of information are not necessarily as objective, however, in their interpretation and dissemination of scientific data as my scientific self would like them to be—influenced as they are by timing, money, convenience, politics, and countless other agendas. I can only hope that the “facts” I receive are objective. Moreover, I hope that any regulations stemming from this science are established for the benefit of my family and society as a whole. But how is the information regarding the effect of BPA on human health being packaged and communicated to the general public? Let's begin by understanding what BPA is and how our modern society relies on it.
In 1952, chemists working with BPA discovered that it could help form a hard, clear plastic called polycarbonate. Polycarbonates make such products as compact discs, sunglasses, bicycle helmets, water and milk bottles, baby bottles, food storage containers, tableware, plastic windows, bullet-resistant laminate, cell phones, car parts, toys, and some medical devices such as incubators, dialysis machines, and blood oxygenators. BPA is also used to make certain resins that are commonly found in the linings of food cans to prevent corrosion, and it is present in some polyvinyl chloride (PVC) plastic products, in white dental fillings, dental sealants, and in some flame retardants. In keeping with its widespread applications, BPA ranks among the highest-volume chemicals manufactured worldwide, with an annual production in 2003 of about 13 billion kilograms [
BPA has been shown to leach from water bottles and food cans into the packaged foodstuffs. It then enters the body through the digestive tract when those foods are consumed. The level of BPA released from plastic depends on the age and wear of the plastic and on exposure to heat. For example, one study showed that small levels of BPA leached from baby bottles subjected to simulated normal uses, including boiling, washing with a bottle brush, and dishwashing [
Naturally, the prevalence of human exposure leads to questions about safety and health. Although the plastic industry continues to assert that BPA is safe, the chemical's endocrine-disrupting properties raise concern about its potential to cause harm. BPA exposure affects the hormonal system, in particular, the pathway involving estrogen; its effects have been studied on cells, tissues, and whole organisms. In adult male mice and rats, effects of BPA exposure—abnormal sperm and reduced fertility—were reversed when exposure stopped [
Many animal studies focus on the effect of BPA exposure during fetal development, when cells and tissues are especially susceptible to hormonal alterations. Not only does BPA disrupt proper functioning of the placenta during gestation, but it causes many deleterious health effects in offspring exposed in utero [
Although BPA was not used in plastics manufacturing until the 1950s, its hormonal activity was reported in 1936 [
Let's step back a moment and consider the roles of United States regulatory agencies such as the FDA and the EPA in determining the so-called safe human exposure level for a chemical. Founded in 1906 the FDA focuses on ensuring safety of food, drugs, and medical products. Much later, in 1970, the EPA was established to protect human health in general and safeguard the environment by consolidating the varied efforts of research, monitoring, standard-setting, and enforcement. Six years after the creation of the EPA, the Toxic Substances Control Act was passed by Congress. This Act gave the EPA the power to control chemicals that pose an unreasonable risk to human health or the environment. In other words, the EPA was charged with determining the safe human exposure level for chemicals. Since taking on this daunting task of monitoring the roughly 75,000 chemicals produced in or imported into the US, the EPA has taken action to reduce the risk of over 3,600 chemicals but has banned or limited the production or use of only five. Currently, the EPA lists the “safe level” for BPA as being 50 micrograms (or 0.00005 grams) of BPA per kilogram of body weight per day [
At this point, you might be wondering why this is the first time you've ever heard of BPA. The information is out there but it is a puzzle to get through. Early studies indicated that BPA did not leach or leached in very small amounts from plastic products, including baby bottles. These studies are often referred to by those in the chemical industry, such as the American Plastics Council—who have a vested interest in maintaining the use of BPA in plastics production, to verify the safety of the products [
Because of this ambiguity, findings can be obscured by those who inform the public, especially those with a vested interest in BPA production and usage. As a result, the media presents a confusing and unclear picture of the health risks of BPA exposure by giving equal weight to statements from independent scientists and those working for industry. The resulting influence of this ambiguity was recently revealed in the spring of 2006 when US state legislators in California, Maryland, and Minnesota attempted to pass legislation that would ban the use of BPA in products aimed at children. None of them passed.
The bills focused on children because they are far more susceptible to adverse affects from chemical exposures than adults, even at very low doses. The biological processes involved in their ongoing development are vulnerable to disruption by BPA and their ability to metabolically detoxify such contaminants is not yet mature. Moreover, children are more likely to be exposed to BPA orally because of their need to put things in their mouth—a purpose for which some BPA-containing products, such as some baby bottles and teething rings, are specifically designed.
The California bill (AB319) was introduced in February 2005, making it the first such legislation to be introduced in any state. Sponsored by Assembly Member Wilma Chan (Democrat), AB319 called for any BPA-containing products, including toys or childcare articles, intended for use by a child 3 years old or younger to be prohibited in the state. (It also sought to ban other harmful chemicals such as phthalates.) Violators of the ban would face civil action, carried out by the Attorney General, and penalties of no less then US$10,000 for each day of violation [
The bill was energetically opposed by stakeholders in the chemical, plastics, baby products, and grocery industries. Under the umbrella organization Coalition for Consumer Choice, the NoAB319 campaign successfully fought the bill both in the media and in the Assembly hearing. In a news release by NoAB319, Steve Hentges, executive director of the Polycarbonate Business Unit of the American Plastics Council, stated that the legislation was “founded on insubstantial claims and unproven hypotheses that lack scientific rigor.”
The contradictory information set forth by the proponents and opponents of the bill ultimately led to its death in the Appropriations Committee, even after an amendment removed the BPA provisions, because of one vote. San Francisco Democrat Leland Yee, according to a spokesman, “decided that the decisions to ban chemicals should be left to health experts, not politicians, especially after scientists gave conflicting testimony at an Assembly hearing last week.” [
At a more local level, the first legislation to ban BPA from products aimed at children passed in the city of San Francisco. The “Stop Toxic Toys” bill was virtually identical to AB319 and was signed into law on June 16, 2006. However, in April 2007, the clause limiting BPA in child-aimed products was repealed pending action at the state level. As a result, no action on BPA-containing products will occur in the city until January 2008, and only then if the state has not taken appropriate actions to reduce its use at the state level. While the initial San Francisco legislation was an important step, such a piecemeal approach to controlling BPA exposure, especially in young children, is not perfect. Companies and businesses are bound to have difficulty conforming to a variety of regulations. Although BPA-free alternatives are often available, consumers in areas with legislation may find a lack of choices when it comes to plastic products on the store shelves. Ideally the national regulatory agencies should step in to minimize these problems.
At the national level, the White House disputes the “low-dose theory” and has proposed funding cuts for EPA research on endocrine disrupting chemicals such as BPA; however, the US Congress has maintained the funding level [
Currently, both the EPA and the European Food Safety Authority (EFSA) have set the “safe” level of exposure to BPA to 0.00005 grams per kilogram of body weight per day. Although difficult to estimate accurately, humans are typically exposed to about 0.000001 grams of BPA per kilogram of body weight per day. This is 50 times lower than the EPA- and EFSA-deemed “safe” limit. Unfortunately, this level of exposure is still significantly higher than the low doses that some studies have shown to cause adverse health effects. Moreover, the levels of BPA found by the Center for Disease Control and Prevention to be present in the bodies of Americans appear to be too high to be explained by exposure to known sources of BPA [
In the meantime, what is the scientist-mother to do? The mother in me still waits anxiously for the regulatory agencies and the legislature to catch up with the research on BPA that the scientist in me appreciates. I have switched my brand of sippy cups to one that doesn't contain BPA (a quick internet search will yield many sites describing these and other BPA-free baby products). Nevertheless, while I feel proactive as I watch my daughter happily drink her water, I still cringe a little bit when she drops the sippy cup, toddles over to her toy bin, and starts to gnaw on her plastic turtle instead.
bisphenol A