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The Life Cycle of a Centrosome

April 12, 2018

The Life Cycle of a Centrosome

A combination of cell fusion, genome editing and live cell imaging by Robert Mahen provides new insights into how the position and number of centrosomes is regulated in vivo.

Image credit: pbio.2003998

Celebrate our 15th Anniversary! Tweet @PLOSBiology #PLOSBIO15

PLOS Biology's XV Collection

04/11/2018

research article

The Aging of Naive T Cells

Sanket Rane, Thea Hogan, Benedict Seddon and Andrew Yates confront a set of mathematical models with multiple novel and published datasets to reveal that naive T cells slowly increase their ability to persist in the body the longer they survive.

Image credit: Flickr user: NIAID

The Aging of Naive T Cells

Recently Published Articles

Current Issue

Current Issue March 2018

04/12/2018

perspective

Paradoxical Extinction of Charismatic Animals

Unbeknown to the public, their most charismatic species are highly threatened. This Perspective by Franck Courchamp, Guillaume Chapron and co-workers suggests that the constant presence of these animals in culture and marketing is deceptive and hinders our support for their conservation.

Image credit: pbio.2003997

Paradoxical Extinction of Charismatic Animals

04/05/2018

meta-research article

Preclinical Evidence for Clinical Trials: Flawed?

Analysis of data from institutional review boards, by Susanne Wieschowski, Daniel Strech and co-workers, shows that risk-benefit analysis for early-phase clinical trials is hindered by insufficient and potentially biased information about the supporting preclinical evidence provided in investigator brochures.

Image credit: nosheep, Pixabay

Preclinical Evidence for Clinical Trials: Flawed?

04/05/2018

method and resources

Protein-Protein Interactions by EM

Nicholas Ariotti, James Rae, Thomas Hall, Robert Parton and colleagues present a new toolkit comprising conditionally-stable GFP and mCherry-binding nanobodies fused to ascorbate peroxidase, which allow high-resolution detection of proteins and (via an ultrastructural ‘split-GFP’ system) protein-protein interactions by electron microscopy.

Protein-Protein Interactions by EM

Image credit: pbio.2005473

04/04/2018

perspective

What Exactly is 'N'?

Stanley Lazic, Charlie Clarke-Williams and Marcus Munafò use an analysis of published animal research to show that nearly half of the studies had an artificially inflated sample size and invalid p-values because pseudo-replication was confused for genuine replication. They discuss the need for clarity regarding "sample size" in cell and animal studies.

What Exactly is 'N'?

Image credit: pbio.2005282

04/09/2018

research article

Nitrosylation and Farnesylation Converse at the Synapse

Susan Robinson, Julie-Myrtille Bourgognon, Joern Steinert and co-authors show that nitric oxide regulates synaptic transmission at the Drosophila neuromuscular junction by post-translationally modifying the fusion clamp protein complexin, thereby altering its farnesylation state and clamping ability.

Nitrosylation and Farnesylation Converse at the Synapse

Image credit: Sue Robinson

04/05/2018

research article

Anticipating Epileptic Seizures

A study of human epileptic patients yields novel insights into how normal physiological brain activity undergoes the transition to seizures over a period of hours.

Anticipating Epileptic Seizures

Image credit: pbio.2002580

03/30/2018

research article

Processing Space and Time in Working Memory

Direct brain recordings from humans reveal that rapid, dynamic interactions between the medial temporal lobe and prefrontal cortex underlie working memory for everyday experiences.


Processing Space and Time in Working Memory

Image credit: pbio.2004274

04/13/2018

plos biologue

XV Collection: From a Smile to a Frown

Michael Laub explores what happens when the antibiotic 1-2 punch backfires, featuring a study from Robert Beardmore and colleagues. Read the original article here.


XV Collection: From a Smile to a Frown

Image credit: flicker user moondustwriter

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